HMN-154

SKU: orb1223241

Description

HMN-154 is a benzenesulfonamide anticancer agent. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner.

Key Properties

• CAS Number: 173528-92-2
• MW: 366.44
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₈N₂O₃S
• SMILES: c1(c(cccc1)/C=C/c1ccncc1)NS(=O)(=O)c1ccc(cc1)OC
• Target: TAM Receptor
• Solubility: In Vitro: DMSO : ≥ 15 mg/mL (40.94 mM)

Bioactivity

• In Vitro:
  HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HMN-154 | HMN 154 | HMN154

Quick Database Links

Gene Symbol

TAM Receptor