HLB-0532259

SKU: orb2945334

Description

HLB-0532259 is a bifunctional PROTAC molecule that induces the degradation of Aurora-A and N-Myc proteins, demonstrating DC50 values in the nanomolar range across various cell lines. It has shown promising antitumor efficacy in preclinical mouse models, supporting its application in cancer research, particularly for studying MYCN-amplified cancers and targeted protein degradation.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2566733-45-5
• MW: 748.827
• Formula: C₄₀H₄₄N₈O₇
• SMILES: O=C(NCCCCCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(C=C4)NC=5N=CC=6C=C(C(=O)N(C)C)N(C6N5)C7CCCC7
• Target: Aurora Kinase,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164830695