HIF-1α-IN-2

SKU: orb1688688

Description

HIF-1α-IN-2 is a potent, novel small molecule inhibitor of HIF-1α, demonstrating dose-dependent suppression of HIF-1α and VEGF expression. It exhibits anticancer activity by inhibiting tumor cell migration and has shown efficacy in both in vitro and in vivo cancer research models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 2762315-06-8
• MW: 361.46
• Purity: >99.99% (May vary between batches)
• Formula: C₂₁H₁₉N₃OS
• SMILES: COc1ccc2c(Nc3cccc(c3)-c3csc(C)n3)cc(C)nc2c1
• Target: HIF,HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:10 mg/mL (27.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.77 mM)

Bioactivity

• Target IC50:
  HIF1α (MDA-MB-231):28 nM|HIF1α (MiaPaCa-2):15 nM
• In Vitro:
  HIF-1α-IN-2 (0-1 μM; 72h) dose-dependently inhibits the expression of HIF-1α and VEGF and suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxic conditions.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIF-1α

Compound Identifiers

PubChem CID

163196195