Hexahydrocurcumin

SKU: orb1296075

Description

Hexahydrocurcumin is an orally bioavailable small molecule that selectively inhibits cyclooxygenase-2 (COX-2) without affecting COX-1. This property makes it a valuable research tool for investigating inflammation, pain, and cancer mechanisms in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 36062-05-2
• MW: 374.43
• Purity: 99.88% (May vary between batches)
• Formula: C₂₁H₂₆O₆
• SMILES: COc1cc(CCC(O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O
• Target: ROS,Reactive Oxygen Species,COX
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM);DMSO:45 mg/mL (120.18 mM)

Bioactivity

• In Vivo:
  In colon cancer rats, Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci. Hexahydrocurcumin also markedly decreases COX-2 protein expression .
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• In Vitro:
  Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) significantly decreased HT-29 colon cancer cell viability in a time- and concentration-dependent manner, with IC50 values of 77.05 μM at 24 hours and 56.95 μM at 48 hours. When combined with 5-fluorouracil (5-FU; 5 μM), Hexahydrocurcumin markedly reduced COX-2 expression without altering COX-1 levels . Moreover, Hexahydrocurcumin (7-14 μM; 24 hours) attenuated LPS-induced prostaglandin E2 (PGE2) increase in murine macrophages (RAW 264.7) in a concentration-dependent manner .
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• Cell Research:
  Cell Line: HT-29 cells. Concentration: 0 μM, 5 μM, 10 μM, 25 μM. Incubation Time: 24 hours or 48 hours
• Animal Research:
  Animal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH). Dosage: 50 mg/kg. Administration: Oral administration; daily; for 16 weeks
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Hexahydrocurcumin, Cyclooxygenase, COX, COX-1, ReactiveOxygenSpecies, Reactive Oxygen Species, ROS

Compound Identifiers

PubChem CID

5318039