Herniarin

SKU: orb1300112

Description

Herniarin (Ayapanin) is a bioactive coumarin compound studied for its antitumor properties. Research indicates it exhibits cytotoxic effects in various cancer cell lines in vitro and has shown potential in modulating signaling pathways relevant to oncology studies.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 531-59-9
• MW: 176.17
• Purity: >99.99% (May vary between batches)
• Formula: C₁₀H₈O₃
• SMILES: O(C)C=1C=C2C(=CC1)C=CC(=O)O2
• Target: Antibacterial,Others,Apoptosis
• Solubility: DMSO:50 mg/mL (283.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.35 mM)

Bioactivity

• In Vitro:
  Herniarin is cytotoxic to the breast carcinoma cell line MCF-7 (IC50: 207.6 μM) and induces apoptosis in MCF-7 cells at 100 μM . While Herniarin alone shows no significant cytotoxicity on transitional cell carcinoma (TCC) cells, it significantly enhances the antitumor effect of cisplatin (5 μg/mL) at 80 μg/mL and increases chromatin condensation .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

7-Methoxycoumarin, Ayapanin, inhibit, Methyl umbelliferyl ether, Inhibitor, Herniarin, Herniarine

Compound Identifiers

PubChem CID

10748