Herniarin

SKU: orb1222093

Description

Herniarin is a natural coumarin with antitumor effect.(In Vitro):Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 μM. Herniarin (100 μM) also induces apoptosis in MCF-7 cells. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 μg/mL cisplatin, Herniarin (80 μg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation.

Key Properties

• CAS Number: 531-59-9
• MW: 176.17
• Purity: >98% (HPLC)
• Formula: C₁₀H₈O₃
• SMILES: COc1ccc2ccc(=O)oc2c1
• Target: Others
• Solubility: DMSO : ≥ 125 mg/mL; 709.54 mM

Bioactivity

• In Vitro:
  Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 μM. Herniarin (100 μM) also induces apoptosis in MCF-7 cells. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 μg/mL cisplatin, Herniarin (80 μg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

7-Methoxycoumarin | Methyl umbelliferyl ether

Quick Database Links

Gene Symbol

Others