Hepln-13

SKU: orb1305328

Description

Hepln-13

Research Area

Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 64369-13-7
• MW: 325.2
• Purity: 99.83%
• Formula: C₁₇H₁₃BrN₂
• SMILES: Brc1ccc(cc1)C1Nc2cccc3cccc(N1)c23
• Target: Serine Protease,Others,c-Met/HGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.15 mM);DMSO:60 mg/mL (184.5 mM)

Bioactivity

• Target IC50:
  Hepsin:0.33 μM
• In Vivo:
  HepIn-13 displays dose-dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes in LPB-Tag/PB-Hepsin mice and blocks prostate cancer metastasis in this animal model.
• In Vitro:
  Hepln-13 (10 μM; 2 hours; 293 cells) inhibits cleavage.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

potent, phenotypes, prostate, Inhibitor, hepsin, Hepln 13, Hepln13, Hepln-13, HGFR, non-toxic, inhibit, overexpression-relevant, orally, cMet/HGFR, c-Met, cMet, cancer

Compound Identifiers

PubChem CID

256658