HBT1

SKU: orb1298638

Description

HBT1 is a glutamate-dependent AMPA receptor potentiator that enhances receptor activity and stimulates BDNF production with minimal intrinsic agonism in primary neurons. This molecule is used in vitro and in vivo to study synaptic plasticity, neuroprotection, and cognitive function in models of neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 489408-02-8
• MW: 386.39
• Purity: 99.52%
• Formula: C₁₆H₁₇F₃N₄O₂S
• SMILES: Cc1cc(nn1CC(=O)Nc1sc2CCCCc2c1C(N)=O)C(F)(F)F
• Target: GluR,iGluR
• Solubility: DMSO:3.87 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD. Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BDNF, AMPA-R, AMPA, inhibit, Ionotropic glutamate receptors, Inhibitor, HBT 1, HBT1, HBT-1, iGluR, LBD, glutamate, primary neurons, S518

Compound Identifiers

PubChem CID

1222102