HBT1

SKU: orb1219460

Description

HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD. Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.

Key Properties

• CAS Number: 489408-02-8
• MW: 386.39
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₇F₃N₄O₂S
• SMILES: Cc1cc(nn1CC(=O)Nc1sc2CCCCc2c1C(N)=O)C(F)(F)F
• Target: GluR
• Solubility: In Vitro: DMSO : 250 mg/mL (647.01 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GluR