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HALOFUGINONE LACTATE
Catalog Number: orb1219325
| Catalog Number | orb1219325 |
|---|---|
| Category | Small Molecules |
| Description | HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS. |
| Target | prolyl-tRNA synthetase|TGF-β |
| Purity | > 98% (HPLC) |
| MW | 504.8 |
| CAS Number | 82186-71-8 |
| Formula | C19H23BrClN3O6 |
| Storage | Storage temperature: -20°C. Stability: ≥ 2 years |
| Note | For research use only |
HALOFUGINONE LACTATE [orb1298633]
99.02%
82186-71-8
504.8
C19H23BrClN3O6
200 mg, 1 ml x 10 mM (in DMSO), 10 mg, 5 mg, 2 mg, 25 mg, 50 mg, 100 mg
