HA-130

SKU: orb1226728

Description

A potent and selective inhibitor of autotaxin with IC50 of 28 nM; shows no effect on chymotryptic, caspase, and tryptic activities of the proteasome, alkaline phosphatase and a broad-spectrum PEDs (IC50>10 uM); inhibits ATX-driven melanoma cell migration and decreases circulating LPA levels in mice.

Key Properties

• CAS Number: 1229652-21-4
• MW: 463.2858
• Purity: >98% (HPLC)
• Formula: C₂₄H₁₉BFNO₅S
• SMILES: OB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O
• Target: Autotaxin
• Solubility: DMSO: ≥ 39 mg/mL

Bioactivity

• In Vivo:
  HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s. c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).
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• In Vitro:
  HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HA130 | HA 130

Quick Database Links

Gene Symbol

Autotaxin