Gymnemagenin

SKU: orb1301532

Description

Gymnemagenin is a selective LXRβ antagonist with demonstrated antihyperglycemic properties. It is a valuable research tool for studying LXRβ's role in glucose metabolism and metabolic disorders, with applications in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 22467-07-8
• MW: 506.71
• Purity: 99.67%
• Formula: C₃₀H₅₀O₆
• SMILES: CC1(C)C[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]4(C)[C@]3(C)C[C@H](O)[C@@]2(CO)[C@@H](O)[C@@H]1O
• Target: Antibiotic,Liver X Receptor
• Solubility: DMSO:30 mg/mL (59.21 mM)

Bioactivity

• In Vivo:
  Gymnemagenin exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. Gymnemagenin decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. Gymnemagenin to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.
• Animal Research:
  Diabetes was induced in overnight-fasted rats by intravenous injection of 200 mg/kg body weight streptozotocin using a 5% solution of freshly prepared streptozotocin in 0.1 M citrate buffer (pH 4.5). Rats in the normal group were injected with a 0.1 M citrate buffer (pH 4.5) solution alone. A total of 40 rats (20 STZ-treated diabetic rats, 20 normal rats) were fed a basal diet for 4 weeks. The rats were divided into four groups (10 rats/group): group 1 (control), rats were fed the basal diet alone; group 2 (G. sylvestre-fed), rats were fed the basal diet plus Gymnemagenin (100 mg/kg/bw/day); group 3 (STZ-treated), STZtreated rats were fed the basal diet alone; group 4 (STZ-treated G. sylvestre-fed), STZ-treated rats were fed the basal diet plus Gymnemagenin (100 mg/kg/bw/day).

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, LXR, Liver X Receptor, LiverXReceptor, Gymnema,sylvestre, Gymnemagenin

Compound Identifiers

PubChem CID

10051937