Guanosine-3',5'-bisdiphosphate

• Catalog Number: orb533239
• Category: Tools
• Description: (p)ppGpp (collective for ppGpp and pppGpp) is a nucleotide based second messenger and a key regulator of stringent stress response in many bacteria. During nutritional starvation (p)ppGpp initiates the switch from bacterial growth into survival mode. Growth is arrested as (p)ppGpp binds RNA polymerase (RNAP) leading to repressed transcription rate of stable RNA (rRNA, tRNA). Instead, transcription of genes involved in biosynthesis of amino acids is enhanced, leading to prolonged survival.
• Concentration: 100 mM-110 mM
• Form/Appearance: solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5
• Purity: ≥ 95% (HPLC)
• MW: Theoretical MW: 603.16 g/mol (free acid); Detected MW: 602.96 g/mol (free acid)
• SMILES: [nH]1c(N)nc2n([C@H]3[C@H](O)[C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)O)OP(=O)(O)OP(=O)(O)O)cnc2c1=O
• Formula: C₁₀H₁₇N₅O₁₇P₄
• Storage: store at -20 °C
• Note: For research use only
• Application notes: Spectroscopic Propertie: λmax 252 nm, ε 13.6 L mmol-1 cm-1 (Tris-HCl, pH 7.5).
• Expiration Date: 12 months from date of receipt.