Guanosine-3',5'-bisdiphosphate

SKU: orb1733777

Description

(p)ppGpp (collective for ppGpp and pppGpp) is a nucleotide based second messenger and a key regulator of stringent stress response in many bacteria. During nutritional starvation (p)ppGpp initiates the switch from bacterial growth into survival mode. Growth is arrested as (p)ppGpp binds RNA polymerase (RNAP) leading to repressed transcription rate of stable RNA (rRNA, tRNA). Instead, transcription of genes involved in biosynthesis of amino acids is enhanced, leading to prolonged survival.

Images & Validation

• Application Notes:
  Spectroscopic Propertie: λmax 252 nm, ε 13.6 L mmol-1 cm-1 (Tris-HCl, pH 7.5).

Key Properties

• MW: Theoretical MW: 603.16 g/mol (free acid); Detected MW: 602.96 g/mol (free acid)
• Purity: ≥ 95% (HPLC)
• Formula: C₁₀H₁₇N₅O₁₇P₄
• SMILES: [nH]1c(N)nc2n([C@H]3[C@H](O)[C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)O)OP(=O)(O)OP(=O)(O)O)cnc2c1=O

Storage & Handling

• Storage: Store at -20 °C. Short term exposure (up to 1 week cumulative) to ambient temperature possible.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3',5'-ppGpp, Guanosine-3'-diphosphate-5'-diphosphate, Lithium salt

Structural formula of Guanosine-3',5'-bisdiphosphate.

Compound Identifiers

PubChem CID

135398637