GSK2795039

SKU: orb1308249

Description

GSK2795039

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1415925-18-6
• MW: 450.56
• Purity: 95.80%
• Formula: C₂₃H₂₆N₆O₂S
• SMILES: CC(C)n1cc(-c2ccc3CCN(C)c3c2)c2c(NS(=O)(=O)c3ccn(C)n3)ccnc12
• Target: Reactive Oxygen Species,ROS,Apoptosis,NADPH
• Solubility: DMSO:40 mg/mL (88.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.44 mM)

Bioactivity

• In Vivo:
  GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour prior) reduces activity in a murine acute pancreatitis model and decreases serum amylase levels induced by systemic cerulein injection.
• In Vitro:
  GSK2795039 (25 μM; 24 hours) mitigates FeSO4 and LPS-induced apoptosis and reduces caspase-3-positive PC12 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK2795039, GSK-2795039, GSK 2795039, NADPH Oxidase, NADPH, NOX, Inhibitor, inhibit, apoptosis, Apoptosis, Reactive Oxygen Species, ReactiveOxygenSpecies, ROS

Compound Identifiers

PubChem CID

71090129