GSK2795039

SKU: orb1219521

Description

GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays). GSK2795039 (25 μM; 24 hours) decreases the combinatory effect of FeSO4 and LPS-increased levels of apoptosis. It also reduced the presence of caspase-3-positive PC12 cells.GSK2795039 (i.p.; 100 mg/kg; 1 hour before) reduces activity in a murine model of acute pancreatitis. It also decreases the levels of serum amylase triggered by systemic injection of cerulein.

Key Properties

• CAS Number: 1415925-18-6
• MW: 450.56
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₆N₆O₂S
• SMILES: CC(C)n1cc(-c2ccc3CCN(C)c3c2)c2c(NS(=O)(=O)c3ccn(C)n3)ccnc12
• Target: NADPH
• Solubility: DMSO:31 mg/mL(68.8 mM)

Bioactivity

• In Vivo:
  GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein. Animal model: C57BL6 mice. Dosage: 100 mg/kg. Administration: Intraperitoneal injection; 100 mg/kg; 1 hour before. Result: Caused 50% reduction in the level of serum amylase activity.
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• In Vitro:
  GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells. Apoptosis Analysis Cell line: PC12 cells. Concentration: 25 μM. Incubation time: 24 hours. Result: Reduced apoptosis among PC12 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NADPH