GSK-25

SKU: orb1302820

Description

GSK-25 is a selective kinase inhibitor with IC50 values of 398 nM for RSK1 and 1000 nM for p70S6K, demonstrating good selectivity over a panel of 31 kinases and minimal cytochrome P450 inhibition (>2.2 µM). It is a valuable research tool for studying RSK signaling pathways in cancer and metabolic disease models, both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 874119-56-9
• MW: 513.33
• Purity: 98.59%
• Formula: C₂₄H₁₆Cl₂F₂N₆O
• SMILES: CC1=C(C(N=C(N1)c1ccnc(Cl)c1)c1ccc(Cl)cc1F)C(=O)Nc1cc2cn[nH]c2cc1F
• Target: ROCK,S6 Kinase,mTOR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.9 mM);DMSO:60 mg/mL (116.88 mM)

Bioactivity

• Target IC50:
  mTOR (p70S6K):1000nM|ROCK1:7 nM|RSK1:398 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, GSK 25, GSK25, GSK-25, inhibit, mTOR (p70S6K), orally, p70S6K, blood, bioavailable, pressure, P450, selective, Ribosomal S6 Kinase (RSK), Rho-associated kinase, Rho-associated protein kinase, Rho-kinase, S6K, S6 Kinase, S6Kinase, ROCK, ROK, RSK1

Compound Identifiers

PubChem CID

11548023