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GSK-25

SKU: orb1223014

Description

GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).

Images & Validation

Key Properties

CAS Number874119-56-9
MW513.34
Purity>98% (HPLC)
FormulaC24H16Cl2F2N6O
SMILESClc1nccc(c1)C=2NC(C)=C(C(N=2)c3ccc(Cl)cc3F)C(=O)Nc4cc5cnnc5cc4F
TargetRSK1| mTOR (p70S6K)
SolubilityIn Vitro: DMSO : 50 mg/mL (97.40 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 150.00
10 mg
$ 200.00
25 mg
$ 300.00
50 mg
$ 460.00
100 mg
$ 750.00