GPX4 degrader-1

SKU: orb3210419

Description

GPX4 degrader-1 (Compound RS-1) is a GPX4 degrader utilizing hydrophobic tag (HyT) technology, demonstrating a DC50 of 8.9 nM in HT1080 cells. It induces GPX4 degradation, triggers ferroptosis, and increases lipid ROS levels. In a mouse breast cancer model, GPX4 degrader-1 exhibits potent antitumor activity.

Key Properties

• CAS Number: 3057531-85-5
• MW: 634.16
• Formula: C₃₈H₃₆ClN₃O₄
• SMILES: C(CCl)(=O)N1[C@H](C2=C(C=3C(N2)=CC=CC3)C[C@@H]1C(OC)=O)C4=CC=C(C(NCCCC(C5=CC=CC=C5)C6=CC=CC=C6)=O)C=C4
• Target: Ferroptosis,Glutathione Peroxidase,ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Ferroptosis,Glutathione Peroxidase,ROS