PROTAC GPX4 degrader-1

SKU: orb1982611

Description

PROTAC GPX4 Degrader-1 (DC-2) is a potent and selective degrader of glutathione peroxidase 4 (GPX4), achieving a DC50 of 30 nM in HT1080 cells. This compound is a valuable chemical tool for investigating ferroptosis and GPX4 biology in both cellular and in vivo research contexts.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2916433-81-1
• MW: 993.5
• Formula: C₅₀H₅₇ClN₁₀O₁₀
• SMILES: O=C1C2=C(NCCCN3CCN(CC3)CC4CCN(CC4)C(COC5=CC=C(C=C5)C(C6=CC=C(C=C6)Cl)N7CCN(CC7)C(C8=NOC(C)=C8[N+]([O-])=O)=O)=O)C=CC=C2C(N1C9C(NC(CC9)=O)=O)=O
• Target: Glutathione Peroxidase,PROTACs,Ferroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168355638