GP210 Rabbit Polyclonal Antibody

SKU: orb157260

Description

The nuclear pore complex (NPC) facilitates bidirectional transport of macromolecules between the nucleus and cytoplasm in eukaryotic cells and is composed of over 100 distinct subunits. A significant number of these subunits belong to a protein family known as nucleoporins (Nups), characterized by the presence of O-linked N-acetylglucosamine residues and a distinctive pentapeptide repeat motif (XFXFG). gp210, also referred to as Nup210 (nucleoporin 210 kDa) or POM210, is a 1,887-amino-acid single-pass type I membrane protein. It localizes to both the endoplasmic reticulum and the nucleus, with specific enrichment at the NPC. Ubiquitously expressed, gp210 shows the highest expression levels in the pancreas, testis, lung, ovary, and liver. As a nucleoporin capable of dimerization, gp210 plays an essential role in NPC assembly, fusion, and structural integrity. Multiple alternatively spliced isoforms of gp210 exist, and the protein is subject to post-translational phosphorylation.

Research Area

Cell Biology

Images & Validation

• Tested Applications: ELISA
• Dilution Range: ELISA=1:5000-10000
• Reactivity: Human
• Predicted Reactivity: Human, Mouse, Rat

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Immunogen: KLH conjugated synthetic peptide derived from human GP210 (1161-1260/1887aa)
• Target: NUP210
• Molecular Weight: 203 kDa
• Purification: Affinity purified by Protein A
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Liquid
• Buffer/Preservatives: 0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol.
• Concentration: 1mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GP210; POM210; 9830001L10; gp190; PO210_HUMAN; NUP210; Nuclear pore protein gp210; Nuclear envelope pore membrane protein POM 210 (POM210); Nucleoporin Nup210; Pore membrane protein of 210 kDa; KIAA0906; PO210_MOUSE; PO210_RAT;

Quick Database Links

Gene Symbol

NUP210

UniProt

Q8TEM1