GMQ hydrochloride

SKU: orb1298777

Description

GMQ hydrochloride is a selective ASIC3 modulator that activates the channel at neutral pH while inhibiting its acid-evoked peak current. This compound is a valuable research tool for investigating ASIC3's role in pain, inflammation, and ischemia in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5361-15-9
• MW: 237.69
• Purity: 99.64% (May vary between batches)
• Formula: C₁₀H₁₂ClN₅
• SMILES: Cl.Cc1nc(NC(N)=N)nc2ccccc12
• Target: Sodium Channel,Others
• Solubility: DMSO:2.38 mg/mL (10.01 mM)

Bioactivity

• In Vitro:
  Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+-activated K+ currents (IK(Ca)), which was reversed by verruculogen or PF1022A, but not by TRAM-39. Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+-activated K+ (BKCa) channels with an EC50 value of 0.95 M. The activation curve of BKCa channels during exposure to GMQ shifted to a lower depolarized potential, with no change in the gating charge of the curve; however, there was a reduction of free energy for channel activation in its presence. As cells were exposed to GMQ, the amplitude of ion currents were suppressed, including delayed rectifying K+ current, voltage-gated Na+ and L-type Ca2+ currents. In Rolf B1.T olfactory sensory neuron, addition of GMQ was able to induce inward current and to suppress peak INa.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GMQ Hydrochloride, GMQ hydrochloride, NSC 403387 hydrochloride, NSC 403387 Hydrochloride, NSC403387 Hydrochloride, NSC-403387 Hydrochloride, acid-sensing ion channel (ASIC)

Compound Identifiers

PubChem CID

12253739