GMQ hydrochloride

SKU: orb1219903

Description

GMQ hydrochloride is a potent and selective acid-sensing ion channel (ASIC) modulator. It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current.Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+-activated K+ currents (IK(Ca)), which was reversed by verruculogen or PF1022A, but not by TRAM-39. Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+-activated K+ (BKCa) channels with an EC50 value of 0.95 M. The activation curve of BKCa channels during exposure to GMQ shifted to a lower depolarized potential, with no change in the gating charge of the curve; however, there was a reduction of free energy for channel activation in its presence. As cells were exposed to GMQ, the amplitude of ion currents were suppressed, including delayed rectifying K+ current, voltage-gated Na+ and L-type Ca2+ currents. In Rolf B1.T olfactory sensory neuron, addition of GMQ was able to induce inward current and to suppress peak INa.

Key Properties

• CAS Number: 5361-15-9
• MW: 237.69
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₂ClN₅
• SMILES: CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl
• Target: ion channel (ASIC)
• Solubility: In Vitro: H2O : 3.33 mg/mL (14.01 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 403387 hydrochloride

Quick Database Links

Gene Symbol

ion channel (ASIC)