Glycyrrhizic acid

SKU: orb1305086

Description

Glycyrrhizic acid, a triterpenoid saponin from licorice, acts as an HMGB1 antagonist. It is utilized in research for investigating cancer, diabetes, and inflammatory diseases, with applications in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1405-86-3
• MW: 822.93
• Purity: 97.51% (May vary between batches)
• Formula: C₄₂H₆₂O₁₆
• SMILES: C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O[C@@H]4[C@H](O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O4)CC3)[H])(C(=O)C=C6[C@@]2(C)CC[C@]7(C)[C@]6(C[C@](C(O)=O)(C)CC7)[H])[H]
• Target: Virus Protease,MAO,Dehydrogenase
• Solubility: 5% DMSO+95% Saline:4.65 mg/mL (5.65 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:257.5 mg/mL (312.91 mM);Ethanol:93 mg/mL (113.01 mM)

Bioactivity

• Target IC50:
  Raji cells:381 μM|Hepatocyte cells:82.4 μM|ECV-304 cells:> 119 μM|MAO:0.16 μM|MDCK cells:39.6 μM|HEK293 cells:0.015 μM
• In Vivo:
  METHODS: To study the anti-inflammatory activity of Glycyrrhizic acid, Glycyrrhizic acid (50 mg/kg) was injected intraperitoneally to iodine-induced NOD.H-2h4 mice. RESULTS: Dihydroartemisinin significantly reduced the levels of TgAb, HMGB1, TNF-α, IL-6, and IL-1β in the mice and effectively alleviated thyroiditis in the mice.
• In Vitro:
  METHODS: MDCK cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was measured using MTT assay. RESULTS: Glycyrrhizic acid inhibited the growth of MDCK cells (EC50=15.2 µM). METHODS: African green monkey Vero E6 cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was determined using MTT assay. RESULTS: Glycyrrhizic acid showed no inhibitory effect on the growth of Vero E6 cells (CC50>100 µM).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dehydrogenase, inhibit, Inhibitor, MAO, Glycyrrhizic acid, Glycyrrhizin, VirusProtease, Virus Protease

Compound Identifiers

PubChem CID

14982