Glutaminase C-IN-1

SKU: orb1223157

Description

GLS-IN-968 is an allosteric inhibitor of glutaminase (GLS). It acts by blocking Rho-GTPase-dependent transformation of fibroblasts and suppressing breast cancer cell growth and invasive activity in vitro.

Key Properties

• CAS Number: 311795-38-7
• MW: 475.43
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₇BrN₂O
• SMILES: CC1(CC2=C(C(Nc3c2c2ccccc2cc3)c2cc(c(cc2)N(C)C)Br)C(=O)C1)C
• Target: Glutaminase C
• Solubility: DMSO : 25 mg/mL. 52.59 mM

Bioactivity

• In Vivo:
  Animal model: SCID mice with P493 B lymphoma cells. Dosage: 200 μg/mouse. Administration: Intraperitoneal injection, daily for 12 days. Result: Caused a ~50% reduction in the size of the tumors.
• In Vitro:
  Cell Viability Assay Cell line: MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells. Concentration: 10 μM. Incubation time: 5 h. Result: Inhibited cell growth.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GLS-IN-968 | Glutaminase inhibitor-968

Quick Database Links

Gene Symbol

Glutaminase C