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GGTI-286

SKU: orb1687664

Description

GGTI-286 is a selective geranylgeranyltransferase I (GGTase I) inhibitor with an IC50 of 2 μM. It potently blocks Rap1A geranylation in cellular models like NIH3T3 cells and is used in vitro to study the role of geranylgeranylated proteins in cancer and cardiovascular research, showing greater selectivity over farnesyltransferase.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number171744-11-9
MW429.58
FormulaC23H31N3O3S
SMILESC(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C2=CC=CC=C2
TargetRas,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information