GCGR antagonist 2

SKU: orb1744784

Description

GCGR Antagonist 2 is a potent, orally bioavailable furan-2-carbohydrazide glucagon receptor antagonist. It binds the human receptor with a Kd of 2.3 nM and inhibits rat receptor activity with an IC50 of 0.43 nM, effectively blocking glucagon-stimulated glycogenolysis. This compound is a valuable tool for studying glucose metabolism in diabetes research, applicable in both in vitro binding assays and in vivo metabolic studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 280134-25-0
• MW: 450.53
• Formula: C₂₈H₂₆N₄O₂
• SMILES: C(N1C=2C(=C(C=NNC(=O)C3=CC(C#N)=C(O)C=C3)C=CC2)C=C1)C4=C(C)C(C)=CC(C)=C4C
• Target: Others,Glucagon Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

85075101