Garcinia lactone

SKU: orb1218234

Description

Garcinia lactone is an anti-obesity agent.Garcinia lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA.

Key Properties

• CAS Number: 27750-13-6
• MW: 190.11
• Purity: >98% (HPLC)
• Formula: C₆H₆O₇
• SMILES: O[C@@](C1)([C@@H](C(O)=O)OC1=O)C(O)=O
• Target: ATPase
• Solubility: In Vitro: DMSO : 250 mg/mL (1315.03 mM)

Bioactivity

• In Vivo:
  (-)-Hydroxycitric acid lactone (1000-3000 mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken. Animal model: 1-day-old male broiler chickens. Dosage: 1000, 2000, 3000 mg/kg. Administration: Fed for a period of 4 weeks. Result: Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-Hydroxycitric acid lactone

Quick Database Links

Gene Symbol

ATPase