FZD8 (M) Antibody, Rabbit Polyclonal

• Catalog Number: orb67040
• Category: Antibodies
• Description: Rabbit polyclonal to FZD8.Frizzled-8 (FZD8) is a receptor for Wnt proteins, which belongs to the G-protein coupled receptorFz/Smo family. FZD8 is a component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-cateninsignaling through inducing aggregation of receptor-ligand complexes into ribosome-sizedsignalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveledproteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt targetgenes. A second signaling pathway involving PKC and calcium fluxes has been seen for some familymembers. FZD8 may be involved in transduction and intercellular transmission of polarity informationduring tissue morphogenesis and/or in differentiated tissues.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: middle region of human FZD8
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 73
• UniProt ID: Q9H461
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-FZD8 antibody,anti-Frizzled8 antibody,anti-Fz
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human MCF7 using FZD8 antibody