Fz7-21

SKU: orb1296689

Description

Fz7-21 is a peptide antagonist of Frizzled-7 (FZD7) that inhibits Wnt/β-catenin signaling. It effectively blocks WNT3A- and WNT1-induced β-catenin stabilization in vitro, with IC50 values of 50-100 nM in various cell lines, making it a valuable research tool for studying Wnt pathway biology and cancer models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• Target: Wnt/beta-catenin
• CAS Number: 2247635-23-8
• MW: 1796.03
• Purity: 99.80% (May vary between batches)
• Formula: C₈₃H₁₁₄N₁₈O₂₃S₂
• SMILES: C([C@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@H](CC(C)C)NC(C)=O)=O)CCC2)CO)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)CCSC)=O)[C@H](C)C)=O)=O)CS)=O)C=5C=6C(NC5)=CC=CC6

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wnt, Wnt–β-catenin, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, βcatenin, bcatenin, (Ac)-LPSDDLEFWCHVMY-NH2, beta-catenin, betacatenin, conformation, inhibit, lipid-binding groove, intestinal organoids, mouse FZD7 CRD, human FZD7 CRD, Fz7 21, FZD7 CRD, FZD7, Fz721, Fz-7-21, Fz7-21, Inhibitor

Compound Identifiers

PubChem CID

155977654