Futuximab Antibody

SKU: orb1980432

Description

Sym004 is a therapeutic antibody mixture comprising futuximab and zatuximab, which bind distinct EGFR epitopes. This dual-targeting approach enhances antitumor efficacy and is investigated in preclinical in vitro and in vivo studies for oncology research, particularly in EGFR-driven cancers.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1310460-85-5
• MW: 146.28 kDa
• Purity: 95.00%
• Target: EGFR

Bioactivity

• In Vivo:
  In the EGFRwt-expressing parazacco spilurus subsp. spilurus xenograft model, Futuximab (50 mg/kg, intraperitoneal injection, twice weekly for 5 consecutive weeks) demonstrated significant antitumor activity .
• In Vitro:
  In NR6M cells, Futuximab (20 µg/mL, 24-48 hours) induced EGFRvIII internalization and caused a slight decrease in EGFRvIII levels .

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR