Furanodienone

SKU: orb1222473

Description

Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependent on the expression of HER2 but not EGFR .

Key Properties

• CAS Number: 24268-41-5
• MW: 230.3
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₈O₂
• SMILES: CC1=CC(=O)C2=C(CC(=CCC1)C)OC=C2C
• Target: HER2
• Solubility: In Vitro: DMSO : 100 mg/mL (434.22 mM)

Bioactivity

• In Vitro:
  Furanodienone (0-573.8 μM; 24 hours) exhibits IC50 values: 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively. Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells. Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34 ± 0.45% to 19.45 ± 2.37% and 27.34 ± 0.79%, in RKO cells at 75 and 150 μM. whereas 12.4 ± 1.08 and 20.64 ± 3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89 ± 0.26%. Western blot analysis. Cell line: RKO and HT-29 cells. Concentration: 0 μM; 50 μM; 100 μM; 150 μM. Incubation time: 24 hours. Result: Increased caspase-9 and -3. Apoptosis Analysis. Cell line: RKO and HT-29 cells. Concentration: 0 μM; 75 μM; 150 μM. Incubation time: 24 hours. Result: Induced apoptosis of colorectal cells (RKO and HT-29).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HER2