Frentizole

SKU: orb1220387

Description

Frentizole an immunosuppressive agent is an inhibitor of the Aβ-ABAD interaction.

Key Properties

• CAS Number: 26130-02-9
• MW: 299.35
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃N₃O₂S
• SMILES: COc1ccc2nc(NC(=O)Nc3ccccc3)sc2c1
• Target: Beta Amyloid
• Solubility: DMSO:3 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  Frentizole (8.2 or 79.9 mg/kg/day for young mice in animal feedings, 52 weeks) can extend the life span of NZB/NZW mice. Animal model: NZB/NZW mice. Dosage: 8.2 or 79.9 mg/kg/day for young mice. Administration: In animal feedings; 52 weeks. Result: Showed that the average lifespan of young untreated mice was 38 weeks, in the low dose group the average lifespan was about 38 weeks, and in the high dose group the lifespan was significantly longer with an average lifespan of about 61 weeks. Significantly suppressed leukocyte counts, compared to a mean peripheral blood leukocyte count of 4160 in control mice, 3217 in low dose treated mice and 3450 in high dose treated mice. Significant increased in terminal neutrophil counts in young low and high dose treated mice compared to control.
• In Vitro:
  Frentizole (500 ng/mL, 48 hours) is effective in inhibiting thymidine incorporation into DNA when adds to lymphocyte cultures alongside mitogens, and significantly inhibits the response to concanavalin A by 58% in a dose-dependent manner in lymphocytes extracted from mice peritoneal cavity. Frentizole (62.5 ng/mL) can effectively inhibit uridine incorporation and the inhibition of uridine incorporation is independent of the phytochemical used.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Beta Amyloid