Fraxinellone

SKU: orb1222413

Description

Fraxinellone has anti-inflammatory properties. Fraxinellone was found to inhibit LPS-induced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production, and to reduce the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the mRNA and protein levels in a dose-dependent manner.

Key Properties

• CAS Number: 28808-62-0
• MW: 232.27
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₆O₃
• SMILES: CC1=C2C(=O)OC(C2(CCC1)C)C3=COC=C3
• Target: MMP
• Solubility: In Vitro: DMSO : 100 mg/mL (430.51 mM)

Bioactivity

• In Vivo:
  Animal model: BALB/c nude mice. Dosage: 30 and 100 mg/kg. Administration: Oral gavage; 30 and 100 mg/kg; every three days; 30 days. Result: Significantly suppressed tumor growth.
  Read more...
• In Vitro:
  Cell Viability Assay Cell line: A549 cells. Concentration: 0 μM, 10 μM, 30 μM, 100 μM. Incubation time: 12 hours. Result: Inhibited the percent of PD-L1 positive cells.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fraxinellone

Quick Database Links

Gene Symbol

MMP