Forsythin

SKU: orb1224959

Description

Extracted from Forsythia suspensa;Suitability:The mixed solvent of chloroform and methanol,DMSO;Store the product in sealed,cool and dry condition.(In Vitro):Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells.Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes.

Key Properties

• CAS Number: 487-41-2
• MW: 534.56
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₄O₁₁
• SMILES: COC1=C(OC)C=C(C=C1)C1OCC2C1COC2C1=C(OC)C=C(OC2OC(CO)C(O)C(O)C2O)C=C1
• Target: p38 MAPK
• Solubility: DMSO: Soluble

Bioactivity

• In Vitro:
  Phillyrin (1-5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells. Phillyrin (1-5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes. RT-PCR Cell line: Human HepG2 hepatocyte cells. Concentration: 1 μM; 2.5 μM; 5 μM Incubation time: 24 hours. Result: Reduced FAS and SREBP-1c mRNA expression.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK