Flutamide

SKU: orb1310563

Description

Flutamide is a non-steroidal antiandrogen with potency comparable to cyproterone acetate in animal models. It is widely used in research to study androgen receptor signaling in prostate cancer, employing both in vitro assays and in vivo xenograft experiments.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13311-84-7
• MW: 276.21
• Purity: 99.41% (May vary between batches)
• Formula: C₁₁H₁₁F₃N₂O₃
• SMILES: C(F)(F)(F)C1=C(N(=O)=O)C=CC(NC(C(C)C)=O)=C1
• Target: Androgen Receptor
• Solubility: DMSO:250 mg/mL (905.11 mM);Ethanol:51 mg/mL (184.64 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.24 mM)

Bioactivity

• Target IC50:
  Androgen receptor:55 nM(Ki)
• In Vivo:
  The concurrent use of Flutamide and leuprorelin can be employed in the treatment of prostate cancer. The active metabolite of Flutamide, Flutamide-OH, binds directly to the androgen receptors in the anterior pituitary of rats (Ki=55 nM). Flutamide does not affect the proliferation of androgen-sensitive clones in the Shionogi SC-115 mouse mammary carcinoma cells when cultured, displaying only antiandrogenic effects without any androgenic activity.
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• In Vitro:
  Flutamide significantly reduced the prostate weight in rats from 319 mg to 245 mg. Co-administration of Flutamide with a luteinizing hormone-releasing hormone (LHRH) agonist compounded side effects, further decreasing prostate weight to 101 mg and markedly diminishing prostatic ornithine decarboxylase (ODC) activity.
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• Cell Research:
  Effect of flutamide on the growth of an androgen-sensitive clone (SEM-l) of mouse mammary carcinoma Shionogi cells in culture. The cells are incubated up to 40 days in medium (MEM + 2% dextran-coated charcoal extracted fetal calf serum) containing the compounds at a concentration of 1 μM. Media are changed every second day.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Flutamide, Inhibitor, inhibit, Androgen Receptor, AndrogenReceptor, SCH 13521, SCH13521, SCH-13521

Compound Identifiers

PubChem CID

3397