2-hydroxy Flutamide

SKU: orb1299590

Description

2-Hydroxyflutamide is an active metabolite of the antiandrogen flutamide, functioning as a competitive antagonist of the androgen receptor (AR). It is widely used in prostate cancer research to investigate AR signaling and therapy resistance in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 52806-53-8
• MW: 292.21
• Purity: 99.45% (May vary between batches)
• Formula: C₁₁H₁₁F₃N₂O₄
• SMILES: CC(C)(O)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
• Target: Androgen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.84 mM);DMSO:25 mg/mL (85.55 mM)

Bioactivity

• In Vitro:
  The pharmacologically active metabolite 2-hydroxy-flutamide, this principle metabolite increased CYP3A metabolism of midazolam in human microsomes (30%) and hepatocytes (110%).
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

prostate cancer, Androgen Receptor, AndrogenReceptor, 2hydroxy Flutamide, 2-hydroxy Flutamide, 2 hydroxy Flutamide, inhibit, Inhibitor, HFT, Flutamide, Hydroxyflutamide

Compound Identifiers

PubChem CID

91649