Fluoxetine HCl

SKU: orb1310602

Description

Fluoxetine hydrochloride (Lilly 110140) is a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant with a favorable side-effect profile. It is widely employed in neuroscience research to study serotonin neurotransmission in both in vitro binding assays and in vivo behavioral models of depression.

Research Area

Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 56296-78-7
• MW: 345.79
• Purity: >98%
• Formula: C₁₇H₁₈F₃NO ∙ HCl
• SMILES: Cl.CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
• Target: Monoamine transporter
• Solubility: Soluble in DMSO (up to 35 mg/ml) or in Water (up to 4 mg/ml)

Bioactivity

• In Vivo:
  Fluoxetine accelerates the maturation of immature neurons. It enhances the proliferation of new cells in the dentate gyrus of the adult rat hippocampus, strengthens neurodependent long-term potentiation in the hippocampal dentate gyrus, and increases the number of proliferating cells in the prefrontal cortex.
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• In Vitro:
  When co-administered in adult male SD rats, fluoxetine and olanzapine induce a robust and sustained increase in extracellular dopamine levels, with concentrations surpassing baseline by 361% and 272%, respectively—significantly higher than when either drug is used alone. Additionally, fluoxetine reverses the prolonged latency of escape caused by unavoidable shocks in adult male SD rats.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY-110,140

Compound Identifiers

PubChem CID

62857