Flunixin meglumin

SKU: orb1225075

Description

Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.(In Vitro):flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages.flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages.(In Vivo):Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2.

Key Properties

• CAS Number: 42461-84-7
• MW: 491.46
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₈F₃N₃O₇
• SMILES: O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
• Target: COX
• Solubility: Ethanol: 8 mg/mL (16.27 mM); Water: 98 mg/mL (199.4 mM); DMSO: 98 mg/mL (199.4 mM)

Bioactivity

• In Vivo:
  Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2. Animal model: Male sheep injected with Carrageenan. Dosage: 1.1 mg/kg. Administration: Intravenous injection; 1.1 mg/kg; once. Result: Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h.
• In Vitro:
  flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages. flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages. Cell Viability Assay Cell line: RAW 264.7 murine macrophages Concentration: 10, 100, 300, and 1000 μM. Incubation time: 2 hours. Result: Inhibited LPS-induced nitric oxide release at concentrations between 100 and 1, 000 μM (P=0.01).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NIH 10250

Quick Database Links

Gene Symbol

COX