FLT3/ITD-IN-2

SKU: orb1686768

Description

FLT3/ITD-IN-2 is a highly potent and selective small molecule inhibitor of FLT3, FLT3-ITD, and the FLT3D835Y mutant, with IC50 values in the sub-nanomolar to low nanomolar range. It effectively blocks FLT3 phosphorylation and suppresses the proliferation of acute myeloid leukemia (AML) cells in vitro, making it a valuable chemical probe for oncology research targeting FLT3-driven leukemias.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2489446-59-3
• MW: 489.49
• Formula: C₂₃H₂₆F₃N₇O₂
• SMILES: C(NC1=C(C(F)(F)F)C=C(C=C1)N2CCOCC2)(=O)C3=C4N(N=C3)C=CC(N[C@@H]5CCCNC5)=N4
• Target: Others,FLT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163408821