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FLT3/ITD-IN-2

SKU: orb1686768

Description

FLT3/ITD-IN-2 is a highly potent and selective small molecule inhibitor of FLT3, FLT3-ITD, and the FLT3D835Y mutant, with IC50 values in the sub-nanomolar to low nanomolar range. It effectively blocks FLT3 phosphorylation and suppresses the proliferation of acute myeloid leukemia (AML) cells in vitro, making it a valuable chemical probe for oncology research targeting FLT3-driven leukemias.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2489446-59-3
MW489.49
FormulaC23H26F3N7O2
SMILESC(NC1=C(C(F)(F)F)C=C(C=C1)N2CCOCC2)(=O)C3=C4N(N=C3)C=CC(N[C@@H]5CCCNC5)=N4
TargetFLT,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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FLT3/ITD-IN-2 (orb1686768)

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