Floxuridine

SKU: orb1310124

Description

Floxuridine

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50-91-9
• MW: 246.19
• Purity: 99.96% (May vary between batches)
• Formula: C₉H₁₁FN₂O₅
• SMILES: OCC1OC(CC1O)N1C=C(F)C(=O)NC1=O
• Target: DNA/RNA Synthesis,Virus Protease,Antibacterial,HSV,Apoptosis,Nucleoside Antimetabolite/Analog
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (20.31 mM);H2O:24.6 mg/mL (99.92 mM);DMSO:262 mg/mL (1064.22 mM)

Bioactivity

• In Vitro:
  Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, CMV, Deoxyfluorouridine, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, Cytomegalovirus, 5-Fluorouracil 2'-deoxyriboside, Bacterial, cancer, Antimetabolite, Analog, Apoptosis, inhibit, NSC 27640, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Oncology, NSC27640, NSC-27640, FUDR, HSV, Floxuridine, Herpes simplex virus, Inhibitor, Ovarian, OVCAR-8, polymerase, Thymidylate synthase, S. aureus, SKOV3ip, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

3363