Floxuridine

SKU: orb1224882

Description

Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50-91-9
• MW: 246.19
• Purity: >98% (HPLC)
• Formula: C₉H₁₁FN₂O₅
• SMILES: O=C1NC(C(F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O
• Target: DNA/RNA Synthesis
• Solubility: Ethanol: 10 mg/mL (40.61 mM); Water: 49 mg/mL (199.03 mM); DMSO: 49 mg/mL (199.03 mM)

Bioactivity

• In Vivo:
  Animal model: C57BL/6 mice injected with S. aureus. Dosage: 0.5-1.25 mg/kg. Administration: once per day for 7 days or single dose. Result: Was a very potent inhibitor for S. aureus infection In vivo.
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• In Vitro:
  Cell Viability Assay Cell line: Ovarian cancer cells. Concentration: 0-25 μM. Incubation time: 4, 8, 24 hours. Result: Was potentiated the sensitivity by PARP inhibitors. Western blot analysis. Cell line: OVCAR-8 and SKOV3ip cells. Concentration: 300 μM. Incubation time: 4, 8, 24 hours. Result: Induced phosphorylation of Chk1 and Chk2 in two ovarian cancer cell lines Cell Cycle Analysis Cell line: A2780, SKOV3ip, OVCAR-5, and OVCAR-3 ovarian cancer cells. Concentration: 0.5, 1.0, 1.5, 2.0, and 2.5 μM Incubation time: 24 hours. Result: Induced cell arrest at G1/S-phase period.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-FDU | 5-Fluorodeoxyuridine | NSC 26740 | NSC 27640

Quick Database Links

Gene Symbol

DNA/RNA Synthesis