FLLL-32

SKU: orb1226745

Description

FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM); induces apoptosis in pancreatic and breast cancer cell lines; also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells; decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines.

Key Properties

• CAS Number: 1226895-15-3
• MW: 464.6
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₂O₆
• SMILES: O=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3
• Target: STAT
• Solubility: DMSO: 85 mg/mL (183 mM); Ethanol: 24 mg/mL (51.7 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vitro:
  FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JAK2 Inhibitor X | FLLL32

Quick Database Links

Gene Symbol

STAT