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FKBP51 Antibody: PerCP

Catalog Number: orb147198

DispatchUsually dispatched within 2-3 weeks
$ 610.00
Catalog Numberorb147198
CategoryAntibodies
DescriptionMouse monoclonal to FKBP51 (PerCP). Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones. One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins. FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex. The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90. Although FKBP52 and FKBP51 share 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics. FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids..
TargetFKBP51
ClonalityMonoclonal
Species/HostMouse
IsotypeIgG1
ConjugationPerCP
ReactivityCanine, Hamster, Human, Mouse, Rabbit, Rat
Concentration1 mg/ml
Buffer/Preservatives95.64mM Phosphate, 2.48mM MES and 2mM EDTA
ImmunogenSynthetic peptide corresponding to the residues of human FKBP51
UniProt IDQ13451
MW51kDa
Tested applicationsELISA, ICC, IF, IHC, WB
Dilution rangeWB (1:2000), ICC/IF (1:1000)
Application notesA 1:2000 dilution was sufficient for detection of FKBP51 in ~50 µg total protein using WB analysis.
Clone NumberHi51B
StorageConjugated antibodies should be stored according to the product label
Alternative namesAIG6 antibody, FK506 binding protein 5 antibody, F
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NoteFor research use only
Entrez2289
NCBINP_001139247.1
FKBP51 Antibody: PerCP

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B. Tissue: MK cells. Species: Mouse. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody at 1:1000. Secondary Antibody: APC Goat Anti-Mouse (red). Counterstain: DAPI (blue) nuclear stain. Cells stained red.

FKBP51 Antibody: PerCP

Western Blot analysis of Human Cervical cancer cell line (HeLa) lysate showing detection of FKBP51 protein using Mouse Anti-FKBP51 Monoclonal Antibody, Clone Hi51B. Load: 15 μg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-FKBP51 Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.

  • FKBP52 Antibody: PerCP [orb147215]

    ELISA,  ICC,  IF,  IHC,  WB

    Canine, Hamster, Human, Mouse, Rat

    Mouse

    Monoclonal

    PerCP

    100 μg
  • FKBP4 Rabbit Polyclonal Antibody (PerCP-Cy5.5) [orb2545985]

    ICC,  IF

    Bovine, Equine, Gallus, Human, Mouse, Porcine, Rabbit, Rat, Sheep

    Rabbit

    Polyclonal

    PerCP/Cy5.5

    100 μl
  • FKBP4 Rabbit Polyclonal Antibody (PerCP) [orb2545986]

    ICC,  IF

    Bovine, Equine, Gallus, Human, Mouse, Porcine, Rabbit, Rat, Sheep

    Rabbit

    Polyclonal

    PerCP

    100 μl
  • FKBP51 Rabbit Polyclonal Antibody (PerCP-Cy5.5) [orb2546009]

    IF

    Bovine, Canine, Equine, Gallus, Human, Rabbit, Sheep

    Mouse, Rat

    Rabbit

    Polyclonal

    PerCP/Cy5.5

    100 μl
  • FKBP51 Rabbit Polyclonal Antibody (PerCP) [orb2546010]

    IF

    Bovine, Canine, Equine, Gallus, Human, Rabbit, Sheep

    Mouse, Rat

    Rabbit

    Polyclonal

    PerCP

    100 μl