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FIN56

SKU: orb1223434

Description

FIN56 is a specific inducer of ferroptosis.

Images & Validation

Key Properties

CAS Number1083162-61-1
MW517.66
Purity>98% (HPLC)
FormulaC25H31N3O5S2
SMILESC1CCC(CC1)NS(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)NC5CCCCC5
TargetOthers
SolubilityDMSO : ≥ 100 mg/mL 193.18 mM H2O : < 0.1 mg/mL

Bioactivity

In Vitro
FIN56 (5 μM) can trigger ferroptosis by inhibition of glutathione peroxidase 4 (GPX4). FIN56 (5 μM, 10 hours) depletes GPX4 protein in HT-1080 cells. Cell Viability Assay Cell line: TP53+/+ and TP53-/- HCT116 cells. Concentration: 5 μM. Incubation time: Result: Triggered ferroptosis. Western blot analysis. Cell line: HT-1080 cells. Concentration: 5 μM. Incubation time: 10 hours. Result: Caused a large decrease in the abundance of GPX4 at the protein level.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FIN56 | FIN-56 | FIN 56

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Protocol Information

FIN56 (orb1223434)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 110.00
10 mg
$ 150.00
25 mg
$ 290.00
50 mg
$ 520.00
100 mg
$ 750.00
500 mg
$ 1,600.00