FGFR1/DDR2 inhibitor 1

SKU: orb1309677

Description

This small molecule is a potent dual inhibitor of DDR2 and FGFR1, exhibiting IC50 values of 3.2 nM and 31.1 nM, respectively. It is a valuable research tool for studying kinase signaling in cancer models, including leukemia cell lines like KG-1, in both in vitro and in vivo experimental settings.

Research Area

Cardiovascular Research, Musculoskeletal & Connective Tissue Research; Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2308497-58-5
• MW: 501.5
• Purity: 99.43% (May vary between batches)
• Formula: C₂₈H₂₂F₃N₅O
• SMILES: Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F
• Target: Discoidin Domain Receptor (DDR),FGFR
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (6.58 mM);DMSO:250 mg/mL (498.5 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• Target IC50:
  DDR2:3.2 nM|FGFR1:31.1 nM |KG-1:108.4 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor, DiscoidinDomainReceptor(DDR), cells, DDR, DDR2, Fibroblast growth factor receptor, FGFR, FGFR1, FGFR1/DDR2 inhibitor 1, FGFR-1/DDR2 inhibitor 1, NCI-H1581, NCI-H2286, Nude, mice, inhibit, Inhibitor, KG-1, phosphorylation, SCID, tumor

Compound Identifiers

PubChem CID

138454761