FGFR Antibody

SKU: orb3169682

Description

Anti-FGFR1/CD331 Antibody is a humanized monoclonal antibody targeting fibroblast growth factor receptor 1 (FGFR1/CD331). FGFR1 is a member of the receptor tyrosine kinase (RTK) family, playing a pivotal role in regulating cell proliferation, survival, migration, and angiogenesis. This antibody specifically binds to the extracellular domain of FGFR1, competitively blocking FGF ligand binding and subsequently inhibiting receptor autophosphorylation and the activation of downstream signaling pathways such as MAPK/ERK and PI3K/Akt. This mechanism effectively suppresses tumor growth and pathological hyperplasia driven by aberrant FGFR1 signaling, making it a valuable tool in research on solid tumors and the development of targeted cancer therapies.

Key Properties

• Antibody Type: Inhibitor Antibody
• Clonality: Monoclonal
• Target: FGFR
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FGFR