FEN1 Inhibitor C2

SKU: orb1220017

Description

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.

Research Area

Epigenetics & Chromatin; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1995893-58-7
• MW: 232.24
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₂N₂O₃
• SMILES: On1c(=O)n(CC2CC2)c2ccccc2c1=O
• Target: hFEN1
• Solubility: DMSO:100 mg/mL (430.59 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FEN1-IN-4

Quick Database Links

Gene Symbol

hFEN1