FEN1-IN-4

SKU: orb1298846

Description

FEN1-IN-4

Research Area

Epigenetics & Chromatin, Immunology & Inflammation

Key Properties

• CAS Number: 1995893-58-7
• MW: 232.24
• Purity: >99.99% (May vary between batches)
• Formula: C₁₂H₁₂N₂O₃
• SMILES: On1c(=O)n(CC2CC2)c2ccccc2c1=O
• Target: FLAP,Others
• Solubility: DMSO:100 mg/mL (430.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (17.22 mM)

Bioactivity

• In Vitro:
  FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, colorectal, colon, cancer, FEN1IN4, FEN-1-IN-4, FEN1-IN-4, FEN1 IN 4, FEN1 Inhibitor C2, endonuclease, human, flap, glioblastoma, hFEN1, Inhibitor, inhibit

Compound Identifiers

PubChem CID

121231495