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FBW7 (N) Antibody, Rabbit Polyclonal

Catalog Number: orb67185

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$ 440.00
Catalog Numberorb67185
CategoryAntibodies
DescriptionRabbit polyclonal to FBW7.F-box/WD repeat-containing protein 7 (FBXW7) is a substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination andsubsequent proteasomal degradation of target proteins. FBXW7 probably recognizes and binds tophosphorylated target proteins. FBXW7 is involved in the degradation of cyclin-E, MYC, NOTCH1released notch intracellular domain (NICD), and probably PSEN1.
ClonalityPolyclonal
Species/HostRabbit
ConjugationUnconjugated
ReactivityHuman
Buffer/Preservatives0.01% NaN3
PurityAffinity purification
ImmunogenN-terminal region of human DDB1
UniProt IDQ969H0
MW80
Tested applicationsWB
Dilution rangeWB:1:1000-1:3000
Storage-20°C
Alternative namesanti-FBW7 antibody,anti-Fbox antibody,anti-WD repe
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NoteFor research use only
FBW7 (N) Antibody, Rabbit Polyclonal

Western blot analysis of total cell extracts from human Hela(Lane1) and human T47D(Lane2) using FBW7 antibody